1330-1349 Black Death Kills 75 Million

This twenty year period covers the reign of Edward III. In this period there was sporadic warfare in the world,  but the most terrible event of this period was the 1348 outbreak of plague -- the Black Death -- which caused 75 million deaths and lasted till 1351.

Then there was the 1332-1333 second War of Scottish Independence, followed by the outbreak of the 1337-1453 Hundred Years' War between England and France, the 1341-1364 Breton War of Succession and the 1346 Serbian conquest of Macedonia and Greece.

The Black Death which swept through Europe during 1348-1351 hit hardest in Avignon, France, killing 3/4 of the population.

Pope Clement VI (who ruled from 1342-1352) personally protected the Jews who were being massacred in Avignon because of rumors that they had started and spread the plague.